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KMID : 1035420170050040049
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Journal of The Korean Society of Integrative Medicine
2017 Volume.5 No. 4 p.49 ~ p.55
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Effect of adjuvant administration on gastrocnemius atrophy induced by ankle joint fixation in rats
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Kim Bum-Hoi
Lee Tae-Sik
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Abstract
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Purpose: In this study we tested the hypothesis that Eucommia ulmoides Extract would improve disuse-induced muscle atrophy following hindlimb immobilization.
Method: The hindlimb immobilization was performed with casting tape to keep the left ankle joint in a fully extended position. The Rats in EU treated group were orally administrated Eucommia ulmoides (EU) water extract. After 2 weeks of immobilization, all animals were sacrificed, and the whole gastrocnemius muscles were dissected from both legs. The morphology of right and left gastrocnemius muscles in both EU and Control groups were assessed by hematoxylin and eosin staining.
Results: Eucommia ulmoides extract represented the significant protective effects against the reductions of the left gastrocnemius muscles weight and average cross section area to compared with Control group.
Conclusion: Eucommia ulmoides has protective effects against immobilization- induced muscle atrophy.
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KEYWORD
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disuse muscle atrophy, eucommia ulmoides, gastrocnemius, hindlimb immobilization
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